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This guidance provides the background information regarding subcutaneous methotrexate as an educational resource for practitioners, with particular reference to safety and best practice; and incorporates new sections on treat-to-target and medication optimisation. Whilst the guidance has been developed for rheumatology practitioners, some aspects may also be of value to health care colleagues working in other specialties including dermatology, gastroenterology and ophthalmology. This publication is supported by grants from Accord, Medac and Nordic.

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